| Active substance |
Methotrexate |
| Also known as |
MTX, Amethopterin |
| Blood pressure |
No direct effect |
| Chemical name |
Methotrexate |
| Dosage (medical) |
Typically 7.5 mg once weekly for rheumatoid arthritis, varying doses for cancer treatment depending on protocol |
| Dosage (sports) |
Not applicable |
| Effects |
Reduces activity of the immune system and interferes with growth of cancer cells |
| Formula |
C20H22N8O5 |
| Half-life |
3 to 10 hours (variable) |
| Hepatotoxicity |
High, requires regular liver function monitoring |
| Lab Test |
Regular monitoring of blood counts and liver function tests |
| Main action |
Inhibits dihydrofolate reductase, leading to a decrease in DNA synthesis and cell reproduction |
| Side effects |
Nausea, vomiting, liver toxicity, lung disease, increased risk of infection, mucositis, alopecia |
| Storage conditions |
Store at room temperature away from light and moisture |
| Strength |
2.5mg |
| Substance class |
Antimetabolite, specifically a folate analog |
| Trade name |
Trexall, Rheumatrex |
| Use in sports |
Not typically used in sports |
| Water Retention |
None |
| Manufacturer |
Johnlee Pharmaceuticals Pvt. Ltd. |
| Packing |
10 tabs/blister |
